Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA7 | P43166 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.41 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3635258 | 0.80 | ALDH1A1 (0.49) | ALDH1A1HTTTSHRSMN1; SMN2TARBP2 | |
| SCHEMBL6819286 | 0.80 | KDM4E (0.48) | ALDH1A1HPGDTSHRKDM4ESMN1; SMN2 | |
| SCHEMBL2815397 | 0.80 | ESR1 (0.44) | ESR1ESR2CA12CA1CA2 | |
| SCHEMBL6819051 | 0.77 | ALDH1A1 (0.43) | ALDH1A1HPGDTSHRKDM4ESMN1; SMN2 | |
| SCHEMBL6818394 | 0.76 | KDM4E (0.51) | ALDH1A1TSHRKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL25170921 | 0.76 | MAPT (0.39) | ESR1ESR2CA12CA1CA2 | |
| SCHEMBL25171020 | 0.74 | KDM4E (0.49) | ALDH1A1HPGDKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL17437927 | 0.74 | CA12 (0.44) | ESR2CA12CA1CA2CA7 | |
| SCHEMBL5985145 | 0.72 | ALDH1A1 (0.55) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL11972313 | 0.70 | CA12 (0.53) | ESR1ESR2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170072-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008157270-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |