Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 4/20 | 0.31 |
| ▸ | EDNRB | P24530 | 2/20 | 0.31 |
| ▸ | EDNRA | P25101 | 2/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.31 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364200 | 0.90 | SMN1; SMN2 (0.34) | KCNN4EDNRBEDNRANR1I2KCNE1 | |
| SCHEMBL364425 | 0.81 | POLB (0.31) | POLB | |
| SCHEMBL3523097 | 0.78 | KCNN4 (0.43) | KCNN4ALDH1A1 | |
| SCHEMBL3523100 | 0.78 | KCNN4 (0.43) | KCNN4ALDH1A1 | |
| SCHEMBL363591 | 0.77 | UHRF1 (0.35) | KCNN4 | |
| SCHEMBL365534 | 0.76 | NPC1 (0.35) | KCNN4POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL363274 | 0.76 | NPC1 (0.35) | KCNN4POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL363076 | 0.74 | EDNRB (0.30) | EDNRBEDNRA | |
| SCHEMBL365351 | 0.72 | CYP19A1 (0.31) | KCNN4 | |
| SCHEMBL363687 | 0.69 | POLB (0.36) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |