Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.32 |
| ▸ | ATP4A | P20648 | 1/20 | 0.32 |
| ▸ | ATP4B | P51164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363274 | 1.00 | NPC1 (0.35) | NPC1RAB9ALMNACNR1CNR2 | |
| SCHEMBL364627 | 1.00 | NPC1 (0.35) | NPC1RAB9ALMNACNR1CNR2 | |
| SCHEMBL363687 | 0.92 | POLB (0.36) | NPC1RAB9ACNR1CNR2POLB | |
| SCHEMBL3523097 | 0.82 | KCNN4 (0.43) | KCNN4TSHRKMT2A | |
| SCHEMBL3523100 | 0.82 | KCNN4 (0.43) | KCNN4TSHRKMT2A | |
| SCHEMBL364200 | 0.82 | SMN1; SMN2 (0.34) | NPC1RAB9ALMNAKCNN4POLB | |
| SCHEMBL364097 | 0.77 | TRPA1 (0.35) | POLB | |
| SCHEMBL364047 | 0.76 | KCNN4 (0.31) | NPC1RAB9ALMNAKCNN4POLB | |
| SCHEMBL361971 | 0.73 | NR1H2 (0.37) | NPC1RAB9AKCNN4KDM4ESMN1; SMN2 | |
| SCHEMBL362974 | 0.73 | KCNN4 (0.35) | RAB9AKCNN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |