Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 6/20 | 0.43 |
| ▸ | HTR2A | P28223 | 6/20 | 0.43 |
| ▸ | DRD3 | P35462 | 6/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3647057 | 0.92 | MRGPRX1 (0.42) | MAOBMRGPRX1DRD2HTR2ADRD3 | |
| SCHEMBL3647141 | 0.87 | MRGPRX1 (0.45) | MAOBMRGPRX1DRD2HTR2ADRD3 | |
| SCHEMBL3649811 | 0.87 | HCRTR1 (0.42) | MAOBMRGPRX1NPC1RAB9AL3MBTL1 | |
| SCHEMBL3641406 | 0.83 | MRGPRX1 (0.46) | MAOBMRGPRX1HCRTR1HCRTR2 | |
| SCHEMBL3641411 | 0.83 | MRGPRX1 (0.46) | MRGPRX1DRD2HTR2ADRD3CHRM1 | |
| SCHEMBL3644111 | 0.82 | HCRTR1 (0.44) | MRGPRX1NPC1HCRTR1HCRTR2 | |
| SCHEMBL3647052 | 0.81 | MRGPRX1 (0.42) | MAOBMRGPRX1HCRTR1HCRTR2 | |
| SCHEMBL3647331 | 0.81 | MAOB (0.59) | MAOBNPC1RAB9AL3MBTL1HCRTR1 | |
| SCHEMBL3647326 | 0.81 | HPGD (0.44) | MAOBMRGPRX1HCRTR1HCRTR2 | |
| SCHEMBL3644110 | 0.80 | HPGD (0.44) | MAOBMRGPRX1NPC1RAB9AHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188282-A2 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009022311-A2 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-02-19 | — | — | WO | disclosed |