SCHEMBL3647331

SCHEMBL3647331

CCCNC(=O)c1cccc2occc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.59
TSHR P16473 2/20 0.47
HTT P42858 1/20 0.47
ALDH1A1 P00352 3/20 0.46
LMNA P02545 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
MTNR1A P48039 2/20 0.44
MTNR1B P49286 2/20 0.44
L3MBTL1 Q9Y468 3/20 0.44
HPGD P15428 3/20 0.42
POLB P06746 2/20 0.42
THRB P10828 1/20 0.42
RECQL P46063 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
GAA P10253 2/20 0.42
NPC1 O15118 1/20 0.42
TP53 P04637 1/20 0.42
RAB9A P51151 1/20 0.42
KMT2A Q03164 2/20 0.42
MEN1 O00255 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3645922 0.87 MAOB (0.45) MAOBTSHRHTTALDH1A1LMNA
SCHEMBL3647326 0.85 HPGD (0.44) MAOBTSHRHTTALDH1A1SMN1; SMN2
SCHEMBL3646147 0.83 MAOB (0.42) MAOBTSHRHTTALDH1A1SMN1; SMN2
SCHEMBL3645101 0.83 LMNA (0.48) MAOBLMNASMN1; SMN2HPGDPOLB
SCHEMBL3645919 0.83 MAOB (0.41) MAOBTSHRMTNR1AMTNR1BHPGD
SCHEMBL3645917 0.82 TSHR (0.41) MAOBTSHRALDH1A1LMNASMN1; SMN2
SCHEMBL3640646 0.82 MTNR1A (0.43) MAOBTSHRALDH1A1SMN1; SMN2MTNR1A
SCHEMBL3646148 0.81 MAOB (0.41) MAOBTSHRALDH1A1MTNR1AMTNR1B
SCHEMBL3648051 0.81 MAOB (0.41) MAOBTSHRHTTALDH1A1LMNA
SCHEMBL3640411 0.81 MAOB (0.41) MAOBTSHRALDH1A1SMN1; SMN2MTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2188282-A2 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS Actelion Pharmaceuticals Ltd. (CH) 2010-05-26 EP disclosed
WO-2009022311-A2 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2009-02-19 WO disclosed