Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.41 |
| ▸ | MAP3K2 | Q9Y2U5 | 2/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.41 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | IL1B | P01584 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3647057 | 0.94 | MRGPRX1 (0.42) | HCRTR1HCRTR2MAOBMRGPRX1TSHR | |
| SCHEMBL3640648 | 0.87 | MAOB (0.48) | HCRTR1HCRTR2MAOBMRGPRX1RAB9A | |
| SCHEMBL3644111 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2MRGPRX1NPC1 | |
| SCHEMBL3644110 | 0.82 | HPGD (0.44) | HCRTR1HCRTR2MAOBMRGPRX1RAB9A | |
| SCHEMBL3649810 | 0.81 | HCRTR1 (0.42) | HCRTR1HCRTR2MAOBMRGPRX1RAB9A | |
| SCHEMBL3647141 | 0.80 | MRGPRX1 (0.45) | HCRTR1HCRTR2MAOBMRGPRX1 | |
| SCHEMBL3641406 | 0.78 | MRGPRX1 (0.46) | HCRTR1HCRTR2MAOBMRGPRX1KMT2A | |
| SCHEMBL3641411 | 0.78 | MRGPRX1 (0.46) | HCRTR1HCRTR2MRGPRX1 | |
| SCHEMBL3647052 | 0.76 | MRGPRX1 (0.42) | HCRTR1HCRTR2MAOBMRGPRX1TSHR | |
| SCHEMBL3647331 | 0.76 | MAOB (0.59) | HCRTR1MAOBRAB9ANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188282-A2 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009022311-A2 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-02-19 | — | — | WO | disclosed |