Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29176483 | 1.00 | MEN1 (0.56) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL30800628 | 1.00 | MEN1 (0.56) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| SCHEMBL25244665 | 0.98 | DNM1 (0.55) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| SCHEMBL25288494 | 0.98 | DNM1 (0.55) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Bromide SCHEMBL25289236 | 0.96 | DNM1 (0.56) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL194044 | 0.96 | MEN1 (0.59) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL11127047 | 0.94 | MEN1 (0.64) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL27803298 | 0.94 | MEN1 (0.58) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| SCHEMBL81000 | 0.94 | DNM1 (0.58) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Hydrogen Sulfide SCHEMBL5998244 | 0.94 | DNM1 (0.58) | MEN1KMT2ATP53SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167516-A1 | PROCESS FOR PRODUCING PHOSPHINE OXIDE VITAMIN D PRECURSORS | Cytochroma Inc. (CA) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008146130-A1 | PROCESS FOR PRODUCING PHOSPHINE OXIDE VITAMIN D PRECURSORS | CYTOCHROMA INC. (CA) | 2008-12-04 | — | — | WO | disclosed |