Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28368237 | 0.85 | MAPT (0.41) | MAPTL3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL29749250 | 0.85 | MAPT (0.41) | MAPTL3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL28901461 | 0.84 | PDE10A (0.47) | MAPTL3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL28368126 | 0.81 | ALDH1A1 (0.59) | MAPTCASP3SENP8SENP7SENP6 | |
| SCHEMBL29749248 | 0.81 | ALDH1A1 (0.59) | MAPTCASP3SENP8SENP7SENP6 | |
| SCHEMBL29929393 | 0.81 | ALDH1A1 (0.47) | MAPTDYRK1APDPK1SMN1; SMN2HPGD | |
| SCHEMBL2116026 | 0.79 | SMN1; SMN2 (0.54) | MAPTL3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL3627491 | 0.79 | DYRK1A (0.39) | MAPTDYRK1APDPK1NPC1RAB9A | |
| SCHEMBL2212181 | 0.79 | ALDH1A1 (0.54) | MAPTL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20893420 | 0.77 | MEN1 (0.53) | MAPTDYRK1APDPK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167077-A2 | ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-03-31 | — | — | EP | claimed |
| WO-2008152099-A2 | ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-12-18 | — | — | WO | claimed |
| CN-110770233-B | Fused bicyclic compound and application thereof in medicine | 广东东阳光药业有限公司 | 2022-07-26 | — | — | CN | disclosed |
| CN-110770233-A | Fused bicyclic compound and application thereof in medicine | 广东东阳光药业有限公司 | 2020-02-07 | — | — | CN | disclosed |