Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 3/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773075 | 0.80 | TAAR1 (0.56) | DPP4TAAR1HTR2AF2CHRNB2 | |
| Hydrochloric Acid SCHEMBL28410804 | 0.78 | TAAR1 (0.54) | DPP4TAAR1HTR2AF2CHRNB2 | |
| SCHEMBL5789702 | 0.78 | DPP4 (0.59) | DPP4TAAR1HTR2AF2 | |
| SCHEMBL851654 | 0.78 | DPP4 (1.00) | DPP4TAAR1HTR2AF2 | |
| SCHEMBL644767 | 0.78 | DPP4 (1.00) | DPP4TAAR1HTR2AF2 | |
| SCHEMBL150159 | 0.78 | DPP4 (1.00) | DPP4TAAR1HTR2AF2 | |
| SCHEMBL1878642 | 0.78 | DPP4 (1.00) | DPP4TAAR1HTR2AF2 | |
| SCHEMBL2067094 | 0.78 | DPP4 (1.00) | DPP4TAAR1HTR2AF2 | |
| SCHEMBL239938 | 0.78 | DPP4 (1.00) | DPP4TAAR1HTR2AF2 | |
| SCHEMBL6933824 | 0.76 | TAAR1 (0.58) | DPP4TAAR1HTR2AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173719-A1 | 4-IMIDAZOLINES AND THEIR USE AS ANTIDEPRESSANTS | F. Hoffmann-Roche AG (CH) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009003867-A1 | 4-IMIDAZOLINES AND THEIR USE AS ANTIDEPRESSANTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-08 | — | — | WO | disclosed |