Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2352155 | 0.81 | MET (0.55) | METNQO2 | |
| SCHEMBL13285276 | 0.80 | MET (0.54) | METNQO2 | |
| SCHEMBL29550022 | 0.78 | MET (0.63) | METNQO2 | |
| SCHEMBL12106977 | 0.78 | MET (0.51) | METNQO2 | |
| SCHEMBL1296500 | 0.78 | MET (0.63) | METNQO2 | |
| SCHEMBL15113557 | 0.76 | MET (0.40) | METLIPG | |
| SCHEMBL3641889 | 0.73 | LIPG (0.39) | METLIPGDGAT1 | |
| SCHEMBL30979659 | 0.72 | MET (0.42) | METNQO2 | |
| SCHEMBL16899788 | 0.71 | LIPG (0.38) | LIPGDGAT1 | |
| SCHEMBL15416425 | 0.69 | IRAK1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164844-A1 | PYRIMIDINYL PYRIDAZINONE DERIVATES | Merck Patent GmbH (DE) | 2010-03-24 | — | — | EP | disclosed |
| WO-2009007074-A1 | PYRIMIDINYL PYRIDAZINONE DERIVATES | MERCK PATENT GMBH (DE) | 2009-01-15 | — | — | WO | disclosed |