Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364927 | 0.92 | SRC (0.51) | KMT2AKDM4EALDH1A1THRBNR4A2 | |
| SCHEMBL364450 | 0.89 | KMT2A (0.47) | KMT2AKDM4EALDH1A1THRBNR4A2 | |
| SCHEMBL364281 | 0.89 | NR4A2 (0.48) | KMT2AKDM4EALDH1A1THRBNR4A2 | |
| SCHEMBL364265 | 0.86 | NR4A2 (0.46) | KMT2AKDM4EALDH1A1THRBNR4A2 | |
| SCHEMBL365250 | 0.85 | NR4A2 (0.45) | KMT2AKDM4EALDH1A1THRBNR4A2 | |
| SCHEMBL365030 | 0.85 | NR4A2 (0.48) | KMT2AKDM4EALDH1A1THRBNR4A2 | |
| SCHEMBL366338 | 0.85 | NR4A2 (0.45) | KMT2AKDM4EALDH1A1THRBNR4A2 | |
| SCHEMBL366488 | 0.85 | NR4A2 (0.45) | KMT2AKDM4EALDH1A1THRBNR4A2 | |
| SCHEMBL365935 | 0.85 | KDM4E (0.47) | KDM4EALDH1A1EGFRSRCPOLB | |
| SCHEMBL367091 | 0.84 | KMT2A (0.44) | KMT2AKDM4EALDH1A1THRBNR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |