Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 4/20 | 0.46 |
| ▸ | SRC | P12931 | 4/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366876 | 0.89 | EGFR (0.44) | KDM4EEGFRSRCAGTR1ALDH1A1 | |
| SCHEMBL366811 | 0.89 | EGFR (0.44) | KDM4EEGFRSRCAGTR1ALDH1A1 | |
| SCHEMBL365259 | 0.89 | KDM4E (0.44) | KDM4EEGFRSRCAGTR1ALDH1A1 | |
| SCHEMBL367205 | 0.85 | EGFR (0.45) | KDM4EEGFRSRCAGTR1ALDH1A1 | |
| SCHEMBL365912 | 0.85 | CES1 (0.45) | KDM4EEGFRSRCAGTR1ALDH1A1 | |
| SCHEMBL366371 | 0.85 | EGFR (0.45) | KDM4EEGFRSRCAGTR1ALDH1A1 | |
| SCHEMBL364339 | 0.85 | KMT2A (0.49) | KDM4EEGFRSRCALDH1A1POLB | |
| SCHEMBL366888 | 0.83 | EGFR (0.44) | KDM4EEGFRSRCAGTR1ALDH1A1 | |
| SCHEMBL366784 | 0.81 | SCN9A (0.50) | EGFRSRCAGTR1 | |
| SCHEMBL365909 | 0.81 | LMNA (0.45) | KDM4EEGFRSRCAGTR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |