Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SYK | P43405 | 6/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3613323 | 0.84 | KDM4E (0.39) | KDM4ESYKSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL3986248 | 0.72 | ALDH1A1 (0.63) | KDM4EIKBKBSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL15652833 | 0.71 | KDM4C (0.48) | KDM4ESYKKCNH2KDM4CPIM2 | |
| Hydrochloric Acid SCHEMBL920573 | 0.71 | ALDH1A1 (0.61) | KDM4EIKBKBSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL27911475 | 0.69 | ALDH1A1 (0.42) | KDM4ESYKSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL4590841 | 0.68 | PTGER4 (0.40) | KDM4EALDH1A1TLR8KMT2AHSD17B10 | |
| SCHEMBL25331044 | 0.67 | POLB (0.57) | KDM4ESMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL1187744 | 0.67 | KDM4E (0.80) | KDM4ESMN1; SMN2ALDH1A1HPGDKMT2A | |
| SCHEMBL3613321 | 0.65 | KDM4E (0.46) | KDM4ESMN1; SMN2ALDH1A1MAPK1KCNH2 | |
| SCHEMBL3608725 | 0.65 | ALDH1A1 (0.40) | KDM4ESYKALDH1A1MAPK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176264-B1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES FOR TREATING HEMATOLOGICAL DISORDERS | BAYER IP GMBH (DE) | 2012-12-19 | — | — | EP | disclosed |
| EP-2137188-B1 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | Bayer Pharma AG (DE) | 2012-06-06 | — | — | EP | disclosed |
| EP-2176264-A1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AND THEIR USE | Bayer Schering Pharma AG (DE) | 2010-04-21 | — | — | EP | disclosed |
| EP-2137188-A2 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-12-30 | — | — | EP | disclosed |
| WO-2009007029-A1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-01-15 | — | — | WO | disclosed |
| WO-2008113469-A2 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-09-25 | — | — | WO | disclosed |