Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3018861 | 0.96 | KMT2A (0.41) | ALDH1A1LMNAMAPK1POLBSMN1; SMN2 | |
| SCHEMBL3006975 | 0.94 | FABP4 (0.42) | ALDH1A1LMNAMAPK1POLBSMN1; SMN2 | |
| SCHEMBL3009426 | 0.88 | MEN1 (0.39) | ALDH1A1LMNAMAPK1POLBMAPT | |
| SCHEMBL3012065 | 0.88 | MAPT (0.40) | ALDH1A1LMNAMAPK1POLBSMN1; SMN2 | |
| SCHEMBL3652634 | 0.87 | MAPT (0.37) | ALDH1A1LMNAPOLBMAPTRECQL | |
| SCHEMBL3017068 | 0.87 | MAPT (0.40) | ALDH1A1LMNAPOLBMAPTRECQL | |
| SCHEMBL3022621 | 0.87 | MAPT (0.40) | ALDH1A1LMNAPOLBMAPTRECQL | |
| SCHEMBL3017999 | 0.86 | MAPT (0.47) | ALDH1A1LMNAMAPK1POLBSMN1; SMN2 | |
| SCHEMBL3011364 | 0.86 | LMNA (0.38) | ALDH1A1LMNAMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL3650838 | 0.86 | FABP4 (0.38) | ALDH1A1LMNAMAPK1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |