Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GCK | P35557 | 4/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3508786 | 0.89 | NPC1 (0.47) | RAB9ANPC1KMT2AMEN1GCK | |
| SCHEMBL2711315 | 0.89 | NPC1 (0.47) | RAB9ANPC1KMT2AMEN1GCK | |
| SCHEMBL3647874 | 0.88 | RAB9A (0.48) | RAB9ANPC1KMT2AMEN1GCK | |
| SCHEMBL3646471 | 0.88 | NPC1 (0.46) | RAB9ANPC1KMT2AMEN1GCK | |
| SCHEMBL3508549 | 0.86 | LMNA (0.47) | RAB9ANPC1KMT2AMEN1GCK | |
| SCHEMBL3508802 | 0.86 | RAB9A (0.49) | RAB9ANPC1KMT2AMEN1GCK | |
| SCHEMBL168243 | 0.85 | MEN1 (0.51) | RAB9ANPC1KMT2AMEN1GCK | |
| SCHEMBL162235 | 0.84 | NPC1 (0.52) | RAB9ANPC1KMT2AMEN1GCK | |
| SCHEMBL3351202 | 0.84 | NPC1 (0.48) | RAB9ANPC1KMT2AMEN1GCK | |
| SCHEMBL2711948 | 0.81 | NPC1 (0.48) | RAB9ANPC1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178837-A2 | ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY | COMENTIS, INC. (US) | 2010-04-28 | — | — | EP | claimed |
| WO-2009015369-A2 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2009-01-29 | — | — | WO | claimed |