Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | TAF1 | P21675 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL836826 | 0.93 | CDK8 (0.57) | CDK8NR4A2CRBNROCK2ROCK1 | |
| SCHEMBL3645569 | 0.79 | CDK8 (0.43) | CDK8NR4A2CRBNROCK2ROCK1 | |
| SCHEMBL9949385 | 0.77 | CDK8 (0.57) | CDK8PDK2 | |
| SCHEMBL10538440 | 0.74 | NOTUM (0.49) | BRD4 | |
| SCHEMBL13702375 | 0.74 | HDAC8 (0.68) | CDK8NR4A2CRBNPDK2CYP17A1 | |
| SCHEMBL12319279 | 0.71 | PLK1 (0.39) | CDK8ROCK2LRRK2HDAC8HDAC6 | |
| SCHEMBL13702359 | 0.70 | CRBN (0.56) | CDK8NR4A2CRBNROCK2PDK2 | |
| SCHEMBL723332 | 0.70 | HDAC8 (0.70) | CDK8CRBNPDK2HDAC8HDAC6 | |
| SCHEMBL388422 | 0.69 | — | — | |
| SCHEMBL5562512 | 0.69 | NOTUM (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183027-A1 | ORGANIC COMPOUNDS | Novartis Ag (CH) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009013335-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-01-29 | — | — | WO | disclosed |