SCHEMBL388422

SCHEMBL388422

O=c1cc(Cl)cn[nH]1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27574284 0.98
SCHEMBL10537216 0.74 AOC3 (0.50)
SCHEMBL10538440 0.71 NOTUM (0.49)
SCHEMBL10537014 0.71 TRPA1 (0.58)
SCHEMBL9031550 0.70
SCHEMBL10788031 0.70
SCHEMBL391604 0.70
SCHEMBL1150386 0.70
SCHEMBL31180495 0.70
SCHEMBL23152175 0.68 S100A4 (0.44)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 277 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106478516-A A kind of synthetic method of 5 chlorine 2H-Pyridazin-3-ones 安徽省鸿鑫生物科技有限公司 2017-03-08 CN claimed
US-20060154930-A1 Substituted amino heterocycles as vr-1 antagonists for treating pain MERCK SHARP & DOHME LTD. (GB) 2006-07-13 US claimed
US-5097028-A Herbicides for crops such as wheat, barley, cotton, soybeans BAYER AKTIENGESELLSCHAFT (DE) 1992-03-17 US claimed
EP-0373425-A2 Substituted pyridazinones, their preparation method and their use as insecticides BAYER AG (DE) 1990-06-20 EP claimed
US-12637426-B2 1-cyano-pyrrolidine compounds as USP30 inhibitors MISSION THERAPEUTICS LIMITED (GB) 2026-05-26 US disclosed
EP-4055016-B1 GPR52 MODULATOR COMPOUNDS NXERA PHARMA UK LTD (GB) 2026-04-29 EP disclosed
EP-4720040-A1 SULFONAMIDE COMPOUNDS BENEFICIAL IN NEUROPROTECTIVE TREATMENT Lario Therapeutics Limited (GB) 2026-04-08 EP disclosed
US-20260085062-A1 NOVEL COMPOUNDS AS CK2 INHIBITORS CAMBRIDGE ENTPR LTD (GB) 2026-03-26 US disclosed
EP-3704094-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-11 EP disclosed
WO-2025264837-A1 NAPHTHYRIDINE GPR52 MODULATORS AND METHODS OF USE THEREOF LIEBER INSTITUTE, INC. (US) 2025-12-26 WO disclosed
EP-4660181-A1 NAV1.7- AND/OR NAV1.8-INHIBITING HYDRAZIDES, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS Eurofarma Laboratórios S.A. (BR) 2025-12-10 EP disclosed
WO-2025235687-A1 LRRK2 INHIBITORS Brenig Therapeutics, Inc. (US) 2025-11-13 WO disclosed
EP-1532120-A1 PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS MERCK SHARP &amp; DOHME LTD. (GB) 2005-05-25 EP disclosed
CN-1545513-A Novel 2H -pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient ����˹ҩ�﹤�� 2004-11-10 CN disclosed
WO-2004074290-A1 SUBSTITUTED AMINO HETEROCYCLES AS VR-1 ANTAGONISTS FOR TREATING PAIN MERCK SHARP & DOHME LIMITED (GB) 2004-09-02 WO disclosed
WO-2004046133-A1 AMINO-HETEROCYCLES AS VR-1 ANTAGONISTS FOR TREATING PAIN MERCK SHARP & DOHME LIMITED (GB) 2004-06-03 WO disclosed
WO-2004014865-A1 PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS MERCK SHARP & DOHME LIMITED (GB) 2004-02-19 WO disclosed
US-5004744-A Durability; effectiveness at low concentration BAYER AKTIENGESELLSCHAFT (DE) 1991-04-02 US disclosed
EP-0373425-A2 Substituted pyridazinones, their preparation method and their use as insecticides BAYER AG (DE) 1990-06-20 EP disclosed
US-3914226-A 5-Chloropyridazones SANDOZ LTD 1975-10-21 US disclosed