Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | NAAA | Q02083 | 1/20 | 0.56 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16117373 | 0.87 | SMN1; SMN2 (1.00) | SMN1; SMN2NAAAL3MBTL1GAAMAPT | |
| SCHEMBL27272636 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2MRGPRX4L3MBTL1GAANPC1 | |
| SCHEMBL18718023 | 0.85 | SMN1; SMN2 (0.72) | SMN1; SMN2NAAAMRGPRX4L3MBTL1GAA | |
| SCHEMBL18970272 | 0.84 | SMN1; SMN2 (0.70) | SMN1; SMN2NAAAMRGPRX4L3MBTL1GAA | |
| SCHEMBL6358483 | 0.83 | SMN1; SMN2 (0.79) | SMN1; SMN2NAAAL3MBTL1TMEM97SIGMAR1 | |
| SCHEMBL13726002 | 0.83 | NPC1 (0.55) | SMN1; SMN2GAANPC1RAB9ATMEM97 | |
| SCHEMBL5256827 | 0.83 | SMN1; SMN2 (0.68) | SMN1; SMN2NAAAMRGPRX4L3MBTL1GAA | |
| SCHEMBL5256832 | 0.83 | SMN1; SMN2 (0.68) | SMN1; SMN2NAAAMRGPRX4L3MBTL1GAA | |
| SCHEMBL4442984 | 0.83 | HSP90AA1 (0.57) | SMN1; SMN2MAPTNPC1RAB9AHPGD | |
| SCHEMBL27556471 | 0.82 | LMNA (0.67) | SMN1; SMN2NPC1RAB9ATMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190827-A1 | N-BENZYL, N' -ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS | N.V. Organon (NL) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009024550-A1 | N-BENZYL, N' -ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS | N.V. ORGANON (NL) | 2009-02-26 | — | — | WO | disclosed |