Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | TP53BP1 | Q12888 | 4/20 | 0.54 |
| ▸ | NAAA | Q02083 | 1/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14233714 | 0.91 | L3MBTL1 (0.63) | SMN1; SMN2TP53BP1NAAAL3MBTL1POLB | |
| SCHEMBL1690505 | 0.88 | NPC1 (0.67) | SMN1; SMN2POLBALDH1A1NPC1RAB9A | |
| SCHEMBL3645530 | 0.85 | SMN1; SMN2 (0.77) | SMN1; SMN2TP53BP1NAAAMRGPRX4L3MBTL1 | |
| SCHEMBL16117373 | 0.85 | SMN1; SMN2 (1.00) | SMN1; SMN2TP53BP1NAAAL3MBTL1POLB | |
| SCHEMBL10026850 | 0.84 | MRGPRX4 (0.54) | SMN1; SMN2MRGPRX4L3MBTL1POLBALDH1A1 | |
| SCHEMBL1690502 | 0.84 | RAB9A (0.68) | SMN1; SMN2POLBALDH1A1NPC1RAB9A | |
| SCHEMBL17032313 | 0.84 | CNR2 (0.48) | SMN1; SMN2L3MBTL1POLBALDH1A1GAA | |
| SCHEMBL1690498 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53BP1L3MBTL1POLBALDH1A1 | |
| SCHEMBL18970272 | 0.82 | SMN1; SMN2 (0.70) | SMN1; SMN2TP53BP1NAAAMRGPRX4L3MBTL1 | |
| SCHEMBL1690504 | 0.81 | NPC1 (0.64) | SMN1; SMN2POLBALDH1A1MAPTKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617224-B2 | Five-membered heterocycles useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-04-11 | — | — | US | disclosed |