Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3150963 | 0.86 | MEN1 (0.38) | S1PR1MEN1KMT2AESR1ESR2 | |
| SCHEMBL3646366 | 0.82 | TP53 (0.39) | ESR2NOTUM | |
| SCHEMBL314833 | 0.75 | BRD4 (0.47) | MEN1KMT2ABRD4BRD2PTGS1 | |
| SCHEMBL2092874 | 0.72 | NR1H4 (0.42) | MEN1KMT2ABRD4BRD2PTGS1 | |
| SCHEMBL6452695 | 0.68 | ALDH1A1 (0.38) | MEN1KMT2ABRD4BRD2PTGS1 | |
| SCHEMBL16863686 | 0.67 | PTGS1 (0.42) | MEN1KMT2ABRD4BRD2PTGS1 | |
| SCHEMBL6452700 | 0.67 | NOTUM (0.43) | PTGS1PTGS2TDO2NR1H4L3MBTL1 | |
| SCHEMBL436193 | 0.64 | CYP1A2 (0.47) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL10552640 | 0.64 | HDAC4 (0.62) | NR1H4 | |
| SCHEMBL7377440 | 0.63 | ABCC4 (0.42) | MEN1KMT2APTGS1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170873-A1 | ISOXAZOLE-IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009000662-A1 | ISOXAZOLE-IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-31 | — | — | WO | disclosed |