Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27559074 | 0.86 | — | — | |
| SCHEMBL1133757 | 0.83 | NR1H2 (0.43) | KDM4EPKMEPHX1NR1H2ALDH1A1 | |
| SCHEMBL5258386 | 0.81 | NCF1 (0.40) | KDM4EPKMEPHX1NR1H2ALDH1A1 | |
| SCHEMBL6974684 | 0.81 | NR1H2 (0.36) | KDM4EPKMNR1H2ALDH1A1KMT2A | |
| SCHEMBL416508 | 0.78 | HPGD (0.51) | KDM4EPKMEPHX1NR1H2GLS | |
| SCHEMBL212033 | 0.77 | CHRM2 (0.42) | KDM4EEPHX1HPGDCHRM2CHRM1 | |
| SCHEMBL3956896 | 0.76 | NCF1 (0.34) | KDM4EPKMNR1H2ALDH1A1KMT2A | |
| SCHEMBL1935995 | 0.76 | CHRM2 (0.34) | KDM4EEPHX1HPGDCHRM2CHRM1 | |
| SCHEMBL30965680 | 0.75 | EPHX1 (0.40) | KDM4EPKMEPHX1ALDH1A1KMT2A | |
| SCHEMBL688432 | 0.74 | HPGD (0.31) | KDM4EPKMHPGDGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176236-A1 | 6-THIOXO-PYRIDAZINE DERIVATIVES | Merck Patent GmbH (DE) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009024221-A1 | 6-THIOXO-PYRIDAZINE DERIVATIVES | MERCK PATENT GBMH (DE) | 2009-02-26 | — | — | WO | disclosed |