SCHEMBL3645972

SCHEMBL3645972

NC(=O)CC(CCNC(=O)c1cccc2occc12)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.40
NPSR1 Q6W5P4 2/20 0.39
EPHX2 P34913 1/20 0.39
ALDH1A1 P00352 6/20 0.38
MAOB P27338 1/20 0.37
KMT2A Q03164 1/20 0.37
HCRTR1 O43613 5/20 0.37
HCRTR2 O43614 2/20 0.37
SMN1; SMN2 Q16637 3/20 0.36
PKM P14618 1/20 0.36
RAB9A P51151 1/20 0.36
MAPT P10636 2/20 0.36
MAPK1 P28482 1/20 0.36
HPGD P15428 3/20 0.36
TSHR P16473 1/20 0.36
KDM4E B2RXH2 1/20 0.35
GLA P06280 1/20 0.35
GAA P10253 1/20 0.35
NSD2 O96028 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3645919 0.80 MAOB (0.41) MAOBKMT2AHCRTR1HCRTR2HPGD
SCHEMBL3645101 0.77 LMNA (0.48) EPHX2MAOBKMT2ASMN1; SMN2RAB9A
SCHEMBL3647326 0.74 HPGD (0.44) ALDH1A1MAOBKMT2AHCRTR1HCRTR2
SCHEMBL3647331 0.74 MAOB (0.59) ALDH1A1MAOBKMT2AHCRTR1SMN1; SMN2
SCHEMBL3645922 0.73 MAOB (0.45) ALDH1A1MAOBKMT2AHCRTR1HCRTR2
SCHEMBL3646932 0.73 HPGD (0.64) NPSR1ALDH1A1KMT2ASMN1; SMN2RAB9A
SCHEMBL3645103 0.73 CTDSP1 (0.57) CYP2C19ALDH1A1KMT2AHPGDKDM4E
SCHEMBL3647214 0.73 MAOB (0.41) ALDH1A1MAOBKMT2AHCRTR1HCRTR2
SCHEMBL3648208 0.73 HPGD (0.46) CYP2C19ALDH1A1KMT2ASMN1; SMN2RAB9A
SCHEMBL3646147 0.72 MAOB (0.42) CYP2C19ALDH1A1MAOBKMT2AHCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2188282-A2 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS Actelion Pharmaceuticals Ltd. (CH) 2010-05-26 EP claimed
WO-2009022311-A2 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2009-02-19 WO claimed
EP-2188282-B1 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2013-01-23 EP disclosed
EP-2188282-A2 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS Actelion Pharmaceuticals Ltd. (CH) 2010-05-26 EP disclosed
WO-2009022311-A2 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2009-02-19 WO disclosed