Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31729516 | 0.89 | KMT2A (0.42) | KMT2ACASP6SCN9AKDM4EHSD17B10 | |
| SCHEMBL5990281 | 0.79 | KDM1A (0.50) | KMT2AKDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL30741486 | 0.79 | CASP6 (0.54) | KMT2ACASP6ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL321538 | 0.76 | COMT (0.44) | KMT2ACASP6SCN9APOLBMEN1 | |
| SCHEMBL29115012 | 0.76 | IDO1 (0.49) | KMT2ACASP6KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL321744 | 0.76 | PDE10A (0.40) | KMT2ACASP6POLBMEN1 | |
| SCHEMBL319508 | 0.74 | TOP2A (0.44) | KMT2AKDM4EHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL321539 | 0.74 | TLR7 (0.39) | KMT2ACASP6SCN9AKDM4EHSD17B10 | |
| SCHEMBL5989423 | 0.73 | KDM1A (0.46) | KMT2AKDM4EHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL5990332 | 0.73 | CYP11B1 (0.51) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-A1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | Pfizer Limited (GB) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007883-A1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LIMITED (GB) | 2012-01-19 | — | — | WO | disclosed |