Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL321538 | 0.81 | COMT (0.44) | CASP6MEN1NPC1RAB9AKMT2A | |
| SCHEMBL28211548 | 0.81 | TRPV4 (0.43) | PDE10APIK3CAPI4KBMAP4K4KCNH2 | |
| SCHEMBL1690921 | 0.79 | KCNH2 (0.42) | PDE10APIK3CAPI4KBMAP4K4KCNH2 | |
| SCHEMBL364780 | 0.76 | KMT2A (0.41) | CASP6MEN1KMT2APOLB | |
| SCHEMBL15674492 | 0.75 | NT5E (0.49) | PIK3CAPI4KBMAP4K4KCNH2MINK1 | |
| SCHEMBL30741486 | 0.73 | CASP6 (0.54) | CASP6MEN1NPC1RAB9AKMT2A | |
| SCHEMBL15674535 | 0.73 | KCNH2 (0.47) | PDE10APIK3CAPI4KBMAP4K4KCNH2 | |
| SCHEMBL15674520 | 0.72 | IDO1 (0.49) | PDE10APIK3CAPI4KBMAP4K4KCNH2 | |
| SCHEMBL27642568 | 0.72 | POLB (0.50) | PDE10APIK3CAPI4KBMAP4K4KCNH2 | |
| SCHEMBL28032644 | 0.71 | LMNA (0.48) | PIK3CAPI4KBMAP4K4KCNH2MINK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590951-A1 | BENZENESULFONAMIDES USEFUL AS SODIUM CHANNEL INHIBITORS | Pfizer Limited (GB) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004743-A1 | BENZENESULFONAMIDES USEFUL AS SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-01-12 | — | — | WO | disclosed |