Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 19/20 | 0.50 |
| ▸ | AURKA | O14965 | 12/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2502255 | 0.69 | P2RX7 (0.39) | KDM4E | |
| SCHEMBL23921726 | 0.69 | USP5 (0.55) | KDM4E | |
| SCHEMBL666598 | 0.67 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKB | |
| SCHEMBL10255608 | 0.66 | RPS6KB1 (0.72) | RPS6KB1AURKAAURKB | |
| SCHEMBL10255955 | 0.66 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKB | |
| SCHEMBL666929 | 0.66 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKB | |
| SCHEMBL2498056 | 0.64 | P2RX7 (0.36) | L3MBTL1 | |
| SCHEMBL31211291 | 0.63 | PARP1 (0.44) | RPS6KB1AURKAAURKBKDM4EL3MBTL1 | |
| SCHEMBL27249587 | 0.63 | PARP1 (0.47) | RPS6KB1AURKAAURKBKDM4EL3MBTL1 | |
| SCHEMBL6135290 | 0.63 | ATM (0.61) | AURKAKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185523-A2 | DERIVATIVES OF 1-OXO-1,2-DIHYDROISOQUINOLINE-5-CARBOXAMIDES AND OF 4-OXO-3,4-DIHYDROQUINAZOLINE-8-CARBOXAMIDES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPEUTICS | Sanofi-Aventis (FR) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009044018-A2 | DERIVATIVES OF 1-OXO-1,2-DIHYDROISOQUINOLINE-5-CARBOXAMIDES AND OF 4-OXO-3,4-DIHYDROQUINAZOLINE-8-CARBOXAMIDES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2009-04-09 | — | — | WO | disclosed |