Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | RECQL | P46063 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014597 | 0.93 | GAA (0.49) | MEN1KMT2ALMNAMAPK1MAPT | |
| SCHEMBL3009747 | 0.90 | GAA (0.53) | MEN1KMT2ALMNAMAPK1MAPT | |
| SCHEMBL3009150 | 0.86 | GAA (0.51) | MEN1KMT2ALMNAMAPK1MAPT | |
| SCHEMBL3649348 | 0.85 | GAA (0.48) | MEN1KMT2ALMNAMAPK1MAPT | |
| SCHEMBL3017612 | 0.84 | ALDH1A1 (0.52) | MEN1KMT2ALMNAMAPK1MAPT | |
| SCHEMBL3011013 | 0.84 | GAA (0.54) | MEN1KMT2ALMNAMAPK1MAPT | |
| SCHEMBL3014974 | 0.83 | CYP3A4 (0.52) | MEN1KMT2ALMNAMAPK1MAPT | |
| SCHEMBL3016505 | 0.83 | GAA (0.53) | KMT2AMAPK1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3020045 | 0.83 | LMNA (0.59) | MEN1KMT2ALMNAMAPK1MAPT | |
| SCHEMBL3003103 | 0.82 | GAA (0.52) | MEN1KMT2ALMNAMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |