Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.50 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21815478 | 0.87 | MEN1 (0.47) | MCOLN3ALPLPOLBTSHRNPSR1 | |
| SCHEMBL28372969 | 0.84 | CA1 (0.37) | MCOLN3MEP1BPOLBTSHRNPSR1 | |
| SCHEMBL4420431 | 0.83 | L3MBTL1 (0.42) | MCOLN3MEP1BPOLBTSHRNPSR1 | |
| SCHEMBL13290903 | 0.82 | MCOLN3 (0.55) | MCOLN3MEP1BACHEALPLPOLB | |
| SCHEMBL20957425 | 0.81 | SMN1; SMN2 (0.40) | MCOLN3MEP1BPOLBTSHRKMT2A | |
| SCHEMBL21812038 | 0.81 | CA1 (0.35) | MCOLN3MEP1BALPLPOLBTSHR | |
| SCHEMBL28548433 | 0.81 | CA1 (0.35) | MCOLN3MEP1BALPLPOLBTSHR | |
| SCHEMBL28560305 | 0.81 | KMT2A (0.46) | NPSR1KMT2AGAAALDH1A1CYP3A4 | |
| SCHEMBL9539690 | 0.81 | NPC1 (0.43) | ALPLTSHRNPSR1KMT2AALDH1A1 | |
| SCHEMBL28950968 | 0.81 | TSHR (0.38) | MCOLN3MEP1BALPLPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104395306-B | The indole derivatives of labeling dye as biomolecule | 皮尔斯生物科技有限公司 | 2019-04-23 | — | — | CN | disclosed |
| EP-3294714-A1 | MORPHINAN DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | Nektar Therapeutics (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2016182840-A1 | MORPHINAN DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | NEKTAR THERAPEUTICS (US) | 2016-11-17 | — | — | WO | disclosed |
| CN-101535279-B | Quinazoline based egfr inhibitors containing a zinc binding moiety | CURIS INC | 2015-05-20 | — | — | CN | disclosed |
| CN-104395306-A | Indole derivatives as labeling dye for biomolecule | PIERCE BIOTECHNOLOGY INC | 2015-03-04 | — | — | CN | disclosed |
| CN-101389628-B | Indolopyridines as EG5 kinesin modulators | 4SC AG | 2013-02-27 | — | — | CN | disclosed |
| WO-2012066065-A1 | PHENYL-HETEROARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-05-24 | — | — | WO | disclosed |
| EP-2190287-A1 | TARTRATE SALTS OR COMPLEXES OF QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | Curis, Inc. (US) | 2010-06-02 | — | — | EP | disclosed |
| CN-101535279-A | Quinazoline based EGFR inhibitors containing a zinc binding moiety | CURIS INC (US) | 2009-09-16 | — | — | CN | disclosed |
| EP-2061772-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | Curis, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2009035718-A1 | TARTRATE SALTS OR COMPLEXES OF QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| CN-101389629-A | Indolopyridines as EG5 kinesin modulators | 4SC AG (DE) | 2009-03-18 | — | — | CN | disclosed |
| CN-101389628-A | Indolopyridines as EG5 kinesin modulators | 4SC AG (DE) | 2009-03-18 | — | — | CN | disclosed |
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008033747-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |