Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857445 | 0.77 | AXL (0.44) | ADORA1ADORA2APDPK1KDRALDH1A1 | |
| SCHEMBL7265442 | 0.70 | PDE3B (0.45) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL1325249 | 0.68 | AXL (0.55) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10671159 | 0.67 | SMN1; SMN2 (0.55) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL13930114 | 0.67 | KDR (0.40) | ADORA1ADORA2APDPK1KDRLOXL2 | |
| SCHEMBL10952826 | 0.66 | CYP11B1 (0.45) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL3650037 | 0.66 | PDE3B (0.44) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL102331 | 0.65 | PDPK1 (0.59) | ADORA1ADORA2APDPK1ALDH1A1LOXL2 | |
| SCHEMBL10564601 | 0.63 | EPHX2 (0.35) | PDE3BPDE3AADORA1ADORA2APDPK1 | |
| SCHEMBL8477225 | 0.62 | MAPT (0.52) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2181111-B1 | THIADIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-06-26 | — | — | EP | disclosed |
| EP-2181111-B1 | THIADIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-06-26 | — | — | EP | disclosed |
| US-8211886-B2 | Thiadiazinone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-07-03 | — | — | US | disclosed |
| US-8211886-B2 | Thiadiazinone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-07-03 | — | — | US | disclosed |
| US-8211886-B2 | Thiadiazinone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-07-03 | — | — | US | disclosed |
| US-20100311733-A1 | THIADIAZINONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT ESCHRANKTER HAFTUNG (DE) | 2010-12-09 | — | — | US | disclosed |
| US-20100311733-A1 | THIADIAZINONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT ESCHRANKTER HAFTUNG (DE) | 2010-12-09 | — | — | US | disclosed |
| US-20100311733-A1 | THIADIAZINONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT ESCHRANKTER HAFTUNG (DE) | 2010-12-09 | — | — | US | disclosed |
| EP-2181111-A1 | THIADIAZINONE DERIVATIVES | Merck Patent GmbH (DE) | 2010-05-05 | — | — | EP | disclosed |
| WO-2009030333-A1 | THIADIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311733-A1 | THIADIAZINONE DERIVATIVES | MET, ABL1, RET | PDE4A 2811/4885PDE4B 3155/4885PDE4C 3274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.