Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 3/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3016494 | 0.95 | VCAM1 (0.47) | VCAM1CYP17A1CYP21A2CYP11B1NPBWR1 | |
| SCHEMBL3019772 | 0.94 | VCAM1 (0.48) | VCAM1CYP17A1CYP21A2CYP11B1NPBWR1 | |
| SCHEMBL3649645 | 0.93 | VCAM1 (0.46) | VCAM1CYP17A1CYP21A2CYP11B1NPBWR1 | |
| SCHEMBL2998933 | 0.91 | VCAM1 (0.49) | VCAM1CYP17A1CYP21A2CYP11B1NPBWR1 | |
| SCHEMBL3015121 | 0.90 | VCAM1 (0.48) | VCAM1CYP17A1CYP21A2CYP11B1NPBWR1 | |
| SCHEMBL3019766 | 0.90 | VCAM1 (0.51) | VCAM1CYP17A1CYP21A2CYP11B1NPBWR1 | |
| SCHEMBL3013323 | 0.89 | VCAM1 (0.48) | VCAM1CYP17A1CYP21A2CYP11B1NPBWR1 | |
| SCHEMBL3008545 | 0.89 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1L3MBTL1MAPTLMNA | |
| SCHEMBL3007276 | 0.88 | VCAM1 (0.51) | VCAM1CYP17A1CYP21A2CYP11B1NPBWR1 | |
| SCHEMBL3012868 | 0.86 | VCAM1 (0.51) | VCAM1CYP17A1CYP21A2CYP11B1NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |