Cyclopropane

Cyclopropane

SCHEMBL3650772

C1CC1.COc1ccc(Oc2ccc(CNC(=O)O)cc2)c(C(F)(F)F)c1

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 9/20 0.47
PTPN7 P35236 2/20 0.47
DUSP3 P51452 2/20 0.47
L3MBTL1 Q9Y468 1/20 0.45
PPARG P37231 3/20 0.44
POLB P06746 2/20 0.44
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL755016 0.91 EPHX2 (0.46) EPHX2PTPN7DUSP3L3MBTL1POLB
SCHEMBL756146 0.84 EPHX2 (0.61) EPHX2POLB
SCHEMBL2542232 0.84 EPHX2 (0.44) EPHX2PTPN7DUSP3L3MBTL1PPARG
SCHEMBL2787720 0.84 EPHX2 (0.41) EPHX2PTPN7DUSP3L3MBTL1PPARG
SCHEMBL2549180 0.84 L3MBTL1 (0.45) EPHX2PTPN7DUSP3L3MBTL1POLB
SCHEMBL754465 0.83 AR (0.40) EPHX2
SCHEMBL765666 0.82 BDKRB1 (0.43) EPHX2PTPN7DUSP3L3MBTL1POLB
Trifluoroacetic Acid SCHEMBL2541472 0.82 HDAC3 (0.43) EPHX2PTPN7DUSP3L3MBTL1PPARG
SCHEMBL2787475 0.82 EPHX2 (0.42) EPHX2PTPN7DUSP3L3MBTL1PPARG
SCHEMBL3642389 0.82 L3MBTL1 (0.43) EPHX2PTPN7DUSP3L3MBTL1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2188254-A1 NOVEL BRADYKININ B1-ANTAGONISTS Boehringer Ingelheim International GmbH (DE) 2010-05-26 EP disclosed
WO-2009027450-A1 NOVEL BRADYKININ B1-ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-03-05 WO disclosed