Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | L3MBTL3 | Q96JM7 | 12/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 11/20 | 0.51 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.49 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.48 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.48 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4528427 | 0.92 | HRH3 (0.56) | HRH3L3MBTL3L3MBTL1KDM2BMBTD1 | |
| SCHEMBL4529106 | 0.89 | HRH3 (0.53) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL4432948 | 0.86 | L3MBTL3 (0.55) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL1789789 | 0.85 | HRH3 (0.65) | HRH3L3MBTL3L3MBTL1KDM2BMBTD1 | |
| SCHEMBL4431692 | 0.85 | L3MBTL3 (0.55) | HRH3L3MBTL3L3MBTL1KDM2BMBTD1 | |
| SCHEMBL4430354 | 0.84 | L3MBTL3 (0.56) | HRH3L3MBTL3L3MBTL1KDM2BMBTD1 | |
| SCHEMBL4516209 | 0.84 | ADRA1A (0.55) | HRH3L3MBTL3L3MBTL1KDM2BADRA1A | |
| SCHEMBL1787573 | 0.83 | HRH3 (0.62) | HRH3L3MBTL3L3MBTL1KDM2BMBTD1 | |
| SCHEMBL4518141 | 0.81 | ADRA1A (0.55) | HRH3L3MBTL3L3MBTL1KDM2BADRA1A | |
| SCHEMBL4439314 | 0.81 | HRH3 (0.49) | HRH3L3MBTL3L3MBTL1KDM2BMBTD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200998-A1 | AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009036117-A1 | AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-03-19 | — | — | WO | claimed |
| EP-2200998-A1 | AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009036117-A1 | AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-03-19 | — | — | WO | disclosed |