Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3651703 | 0.89 | NR1H4 (0.42) | P4HBMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL3649388 | 0.88 | MEN1 (0.40) | P4HBMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2907586 | 0.84 | EPHX1 (0.41) | MEN1KMT2ARAB9ANPC1CYP3A4 | |
| SCHEMBL3650434 | 0.84 | KMT2A (0.41) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL3649241 | 0.83 | NR1H4 (0.45) | KMT2ARAB9ANPC1CYP3A4KCNH2 | |
| SCHEMBL3651507 | 0.82 | RAB9A (0.44) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL3652035 | 0.81 | EPHX2 (0.47) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL3652322 | 0.80 | CYP3A4 (0.37) | MEN1KMT2ARAB9ANPC1CYP3A4 | |
| SCHEMBL3654059 | 0.79 | EPHX1 (0.44) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL3653797 | 0.79 | RAB9A (0.45) | MEN1KMT2ARAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188263-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. Hoffmann-Roche AG (CH) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009027264-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-03-05 | — | — | WO | disclosed |