Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3651333 | 0.92 | NPC1 (0.42) | RAB9ANPC1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3648320 | 0.91 | MEN1 (0.51) | KMT2ARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL3650741 | 0.90 | MAPT (0.47) | KMT2ARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL3650592 | 0.90 | SMN1; SMN2 (0.53) | KMT2ARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL3651170 | 0.89 | NPC1 (0.40) | KMT2ARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL3645321 | 0.87 | MEN1 (0.50) | KMT2ARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL3653797 | 0.87 | RAB9A (0.45) | KMT2ARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL3649241 | 0.86 | NR1H4 (0.45) | KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3649148 | 0.85 | NPC1 (0.42) | KMT2ARAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL3653137 | 0.84 | P4HB (0.40) | KMT2ARAB9ANPC1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188263-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. Hoffmann-Roche AG (CH) | 2010-05-26 | — | — | EP | claimed |
| WO-2009027264-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-03-05 | — | — | WO | claimed |
| EP-2188263-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. Hoffmann-Roche AG (CH) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009027264-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-03-05 | — | — | WO | disclosed |