Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3002536 | 0.92 | EPHX2 (0.48) | EPHX2MAPTKDM4EL3MBTL1TSHR | |
| SCHEMBL3011341 | 0.92 | NPSR1 (0.42) | MAPTUSP2RECQLHSD17B10KDM4E | |
| SCHEMBL3012685 | 0.88 | KMT2A (0.45) | MAPTUSP2RECQLHSD17B10KDM4E | |
| SCHEMBL3001008 | 0.87 | MAPT (0.49) | MAPTUSP2RECQLHSD17B10TSHR | |
| SCHEMBL3012030 | 0.85 | HSD17B10 (0.48) | MAPTUSP2RECQLHSD17B10KDM4E | |
| SCHEMBL3010155 | 0.84 | LMNA (0.42) | EPHX2MAPTKDM4EL3MBTL1TSHR | |
| SCHEMBL3006920 | 0.84 | LMNA (0.42) | EPHX2MAPTKDM4EL3MBTL1TSHR | |
| SCHEMBL3009944 | 0.84 | SMN1; SMN2 (0.44) | MAPTUSP2RECQLHSD17B10KDM4E | |
| SCHEMBL3653349 | 0.84 | ALDH1A1 (0.48) | MAPTUSP2RECQLHSD17B10KDM4E | |
| SCHEMBL3008378 | 0.84 | EPHX2 (0.47) | EPHX2MAPTKDM4ETSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |