Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | GBA1 | P04062 | 2/20 | 0.42 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3002340 | 0.96 | L3MBTL1 (0.50) | L3MBTL1MAPTHSD17B10USP2RECQL | |
| SCHEMBL3010945 | 0.93 | HTT (0.51) | USP2POLBHTTALDH1A1LMNA | |
| SCHEMBL3009774 | 0.89 | MAPT (0.49) | L3MBTL1MAPTHSD17B10USP2RECQL | |
| SCHEMBL3011882 | 0.89 | MAPT (0.52) | L3MBTL1MAPTHSD17B10USP2RECQL | |
| SCHEMBL3016067 | 0.88 | ALDH1A1 (0.51) | MAPTHSD17B10USP2RECQLPOLB | |
| SCHEMBL3014785 | 0.88 | POLB (0.49) | L3MBTL1MAPTHSD17B10USP2RECQL | |
| SCHEMBL3011319 | 0.87 | HTT (0.51) | USP2POLBHTTALDH1A1LMNA | |
| SCHEMBL3009537 | 0.87 | POLB (0.52) | L3MBTL1MAPTPOLBHTTALDH1A1 | |
| SCHEMBL3016124 | 0.87 | HTT (0.51) | POLBHTTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3010397 | 0.86 | ALDH1A1 (0.59) | L3MBTL1MAPTHSD17B10USP2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |