SCHEMBL3654239

SCHEMBL3654239

[CH2]C(C)(C)c1ccc(Cl)cc1Cl

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.60
CYP3A4 P08684 4/20 0.60
TDP1 Q9NUW8 3/20 0.60
MAPK1 P28482 2/20 0.60
TP53 P04637 3/20 0.46
HSD17B10 Q99714 2/20 0.41
CASR P41180 1/20 0.41
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
LMNA P02545 2/20 0.39
HTT P42858 1/20 0.39
CYP2A6 P11509 1/20 0.38
IDO1 P14902 1/20 0.37
ALDH1A1 P00352 1/20 0.36
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
CASP1 P29466 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
SLC6A2 P23975 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL799844 0.83 TSHR (0.62) TSHRCYP3A4TDP1MAPK1TP53
SCHEMBL21995301 0.81 TSHR (0.60) TSHRCYP3A4TDP1MAPK1TP53
SCHEMBL18243045 0.81 TSHR (0.60) TSHRCYP3A4TDP1MAPK1TP53
SCHEMBL15926256 0.79 TSHR (0.58) TSHRCYP3A4TDP1MAPK1TP53
SCHEMBL16211981 0.79 TSHR (0.58) TSHRCYP3A4TDP1MAPK1TP53
SCHEMBL16579369 0.79 TSHR (0.58) TSHRCYP3A4TDP1MAPK1TP53
SCHEMBL9239974 0.79 TSHR (0.58) TSHRCYP3A4TDP1MAPK1TP53
SCHEMBL19445301 0.79 TSHR (0.52) TSHRCYP3A4TDP1MAPK1TP53
SCHEMBL837308 0.79 TSHR (0.52) TSHRCYP3A4TDP1MAPK1TP53
SCHEMBL7913316 0.77 TSHR (0.61) TSHRCYP3A4TDP1MAPK1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2207773-A2 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF Otsuka Pharmaceutical Co., Ltd. (JP) 2010-07-21 EP disclosed
EP-2089373-A1 STAT3/5 ACTIVATION INHIBITOR OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2009-08-19 EP disclosed
WO-2009057811-A2 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2009-05-07 WO disclosed
EP-1957073-A2 MEDICINAL DRUG OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2008-08-20 EP disclosed
WO-2008044667-A1 STAT3/5 ACTIVATION INHIBITOR OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2008-04-17 WO disclosed
WO-2007066784-A2 DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-06-14 WO disclosed
EP-1773797-A2 AROMATIC COMPOUNDS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-04-18 EP disclosed
WO-2006014012-A2 AROMATIC COMPOUNDS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-02-09 WO disclosed