Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL358633 | 0.92 | KMT2A (0.38) | TSHRL3MBTL1NR4A2KMT2AKDM4E | |
| SCHEMBL366048 | 0.91 | NR4A2 (0.36) | TSHRL3MBTL1NR4A2KMT2AKDM4E | |
| SCHEMBL365515 | 0.86 | NR4A2 (0.35) | TSHRL3MBTL1NR4A2KMT2AGAA | |
| SCHEMBL365428 | 0.85 | KMT2A (0.47) | L3MBTL1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL364860 | 0.80 | KMT2A (0.39) | TSHRL3MBTL1NR4A2KMT2AKDM4E | |
| SCHEMBL364924 | 0.78 | ALDH1A1 (0.40) | L3MBTL1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL366161 | 0.78 | ELANE (0.37) | NR4A2KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL358632 | 0.77 | KMT2A (0.47) | L3MBTL1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL365340 | 0.77 | NR4A2 (0.39) | TSHRL3MBTL1NR4A2KMT2AKDM4E | |
| SCHEMBL366305 | 0.77 | NR4A2 (0.41) | TSHRL3MBTL1NR4A2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |