Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3015252 | 0.97 | GAA (0.52) | REV1GAAKMT2AMAPTRECQL | |
| SCHEMBL15671706 | 0.96 | REV1 (0.54) | REV1GAAKMT2AMAPTRECQL | |
| SCHEMBL3010901 | 0.91 | KMT2A (0.57) | REV1GAAKMT2AMAPTRECQL | |
| SCHEMBL3022575 | 0.90 | KMT2A (0.58) | REV1GAAKMT2AMAPTRECQL | |
| SCHEMBL3017824 | 0.89 | MAPT (0.47) | REV1GAAKMT2AMAPTRECQL | |
| SCHEMBL3019394 | 0.89 | REV1 (0.51) | REV1GAAKMT2AMAPTRECQL | |
| SCHEMBL3009903 | 0.88 | GAA (0.54) | REV1GAAKMT2AMAPTRECQL | |
| SCHEMBL3010407 | 0.87 | REV1 (0.57) | REV1KMT2AMAPTRECQLUSP2 | |
| SCHEMBL3019105 | 0.87 | ALDH1A1 (0.52) | REV1KMT2AMAPTRECQLUSP2 | |
| SCHEMBL3011654 | 0.87 | POLB (0.56) | GAAKMT2AMAPTRECQLUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |