Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11828154 | 0.83 | TSHR (0.55) | TSHRACP3HIF1ACYP2C9CYP2C19 | |
| SCHEMBL4551417 | 0.81 | ACP3 (0.42) | TSHRALOX15ACP3DAONAPRT | |
| SCHEMBL521541 | 0.81 | IDO1 (0.53) | TSHRACP3HIF1ACYP2C9CYP2C19 | |
| SCHEMBL29901560 | 0.81 | IDO1 (0.53) | TSHRACP3HIF1ACYP2C9CYP2C19 | |
| SCHEMBL7133356 | 0.79 | TSHR (0.60) | TSHRALOX15DAONAPRTRXRA | |
| SCHEMBL11639869 | 0.78 | TSHR (0.47) | TSHRACP3HPGDHIF1ACYP2C9 | |
| SCHEMBL28546831 | 0.78 | TSHR (0.47) | TSHRACP3HIF1ACYP2C9CYP2C19 | |
| SCHEMBL7873189 | 0.77 | TSHR (0.66) | TSHRACP3HPGDHIF1ACYP2C9 | |
| SCHEMBL11644649 | 0.74 | TSHR (0.43) | TSHRACP3SRD5A2HIF1ACYP2C9 | |
| SCHEMBL4353113 | 0.74 | TSHR (0.54) | TSHRALOX15DAONAPRTRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-A1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | Pfizer Limited (GB) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007883-A1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LIMITED (GB) | 2012-01-19 | — | — | WO | disclosed |