Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terfenadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 7/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.61 |
| ▸ | HTR2A | P28223 | 5/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | DRD3 | P35462 | 3/20 | 0.61 |
| ▸ | HTR2B | P41595 | 3/20 | 0.61 |
| ▸ | BLM | P54132 | 3/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.61 |
| ▸ | DRD1 | P21728 | 3/20 | 0.61 |
| ▸ | HRH2 | P25021 | 3/20 | 0.61 |
| ▸ | HTR2C | P28335 | 3/20 | 0.61 |
| ▸ | THPO | P40225 | 3/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terfenadine SCHEMBL8887396 | 0.92 | LMNA (0.59) | KCNH2HRH1HTR2ACHRM2CHRM1 | |
| Fexofenadine SCHEMBL361347 | 0.86 | LMNA (0.73) | KCNH2HRH1HTR2ACHRM2CHRM1 | |
| Terfenadine SCHEMBL27965234 | 0.79 | KCNH2 (0.98) | KCNH2HRH1HTR2ACHRM2CHRM1 | |
| R-Terfenadine SCHEMBL155924 | 0.78 | KCNH2 (1.00) | KCNH2HRH1HTR2ACHRM2CHRM1 | |
| SCHEMBL11857869 | 0.78 | KCNH2 (1.00) | KCNH2HRH1HTR2ACHRM2CHRM1 | |
| Terfenadine SCHEMBL5152 | 0.78 | KCNH2 (1.00) | KCNH2HRH1HTR2ACHRM2CHRM1 | |
| Terfenadine SCHEMBL5998456 | 0.78 | KCNH2 (1.00) | KCNH2HRH1HTR2ACHRM2CHRM1 | |
| Terfenadine SCHEMBL5999023 | 0.78 | KCNH2 (1.00) | KCNH2HRH1HTR2ACHRM2CHRM1 | |
| Terfenadine SCHEMBL5999024 | 0.78 | KCNH2 (1.00) | KCNH2HRH1HTR2ACHRM2CHRM1 | |
| Terfenadine SCHEMBL3752491 | 0.78 | LMNA (0.66) | KCNH2HRH1HTR2ACHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2192894-A2 | NOVEL METHOD FOR PRODUCING DRY HYDRODISPERSIBLE PHARMACEUTICAL FORMS | Coretecholding (FR) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009024686-A2 | NOVEL METHOD FOR PRODUCING DRY HYDRODISPERSIBLE PHARMACEUTICAL FORMS | CORETECHOLDING (FR) | 2009-02-26 | — | — | WO | disclosed |