Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terfenadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.59 |
| ▸ | HTR2A | P28223 | 4/20 | 0.59 |
| ▸ | BLM | P54132 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.59 |
| ▸ | HTR2B | P41595 | 3/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.59 |
| ▸ | HRH2 | P25021 | 3/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | DRD2 | P14416 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terfenadine SCHEMBL3654979 | 0.92 | KCNH2 (0.61) | LMNAHRH1KCNH2HTR2ABLM | |
| Fexofenadine SCHEMBL361347 | 0.87 | LMNA (0.73) | LMNAHRH1KCNH2HTR2ABLM | |
| Terfenadine SCHEMBL7614378 | 0.82 | LMNA (0.52) | LMNAHRH1KCNH2HTR2ABLM | |
| Fexofenadine SCHEMBL28568251 | 0.78 | HRH1 (0.91) | LMNAHRH1KCNH2HTR2ABLM | |
| Terfenadine SCHEMBL27965234 | 0.78 | KCNH2 (0.98) | LMNAHRH1KCNH2HTR2ABLM | |
| R-Terfenadine SCHEMBL7713984 | 0.77 | KCNH2 (0.88) | LMNAHRH1KCNH2HTR2ABLM | |
| Terfenadine SCHEMBL7713983 | 0.77 | KCNH2 (0.88) | LMNAHRH1KCNH2HTR2ABLM | |
| Terfenadine SCHEMBL5999024 | 0.77 | KCNH2 (1.00) | LMNAHRH1KCNH2HTR2ABLM | |
| Terfenadine SCHEMBL5998456 | 0.77 | KCNH2 (1.00) | LMNAHRH1KCNH2HTR2ABLM | |
| R-Terfenadine SCHEMBL155924 | 0.77 | KCNH2 (1.00) | LMNAHRH1KCNH2HTR2ABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658919-A | LIQUID ACETAMINOPHEN MIXTURE COMPRISING AT LEAST ONE ADDITIONAL ACTIVE DRUG, A SUSPENDING SYSTEM AND A TASTE MASKING COMPOSITION | MCNEIL-PPC, INC. (US) | 1997-08-19 | — | — | US | disclosed |