Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Paricalcitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR known ✓ | P11473 | 13/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.57 |
| ▸ | PGR | P06401 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paricalcitol SCHEMBL12553223 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL12915640 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL12464969 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL12464945 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL25447329 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL21836180 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL24066861 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL6750666 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL13575779 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL12397908 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5306 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20250381202-A1 | PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY | ZOUNEK ALEX (DE) | 2025-12-18 | — | — | US | claimed |
| US-20250339399-A1 | SUPRAMOLECULAR SELF-ASSEMBLY SYSTEM | BEIJING CREATRON INSTITUTE OF PHARMACEUTICAL RES CO LTD (CN) | 2025-11-06 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| WO-2025133218-A1 | PYRAZINE DERIVATIVES FOR THE TREATMENT OF SKIN DISORDERS | PHAMRI NORDEN AB (SE) | 2025-06-26 | — | — | WO | claimed |
| WO-2025129271-A1 | LIPID DELIVERY VEHICLE | THE UNIVERSITY OF QUEENSLAND (AU) | 2025-06-26 | — | — | WO | claimed |
| WO-2025122686-A1 | COMPOSITIONS AND METHODS FOR TREATING OBESITY | YALE UNIVERSITY (US) | 2025-06-12 | — | — | WO | claimed |
| WO-2025122021-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF), THROUGH TARGETING OF S100A9 AND CORRESPONDING DIMER PARTNER AND RECEPTORS | I3S - INSTITUTO DE INVESTIGAÇÃO E INOVAÇÃO EM SAÚDE, ASSOCIAÇÃO (PT) | 2025-06-12 | — | — | WO | claimed |
| WO-2025108575-A1 | METHODS OF SELECTIVE DEPROTECTION AND SYNTHESIS OF TRANSHYDRINDANE- SKELETON-BASED COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2025-05-30 | — | — | WO | claimed |
| WO-2025111447-A1 | TREATMENT OF CANCER WITH DRUG COMBINATIONS | FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES (US) | 2025-05-30 | — | — | WO | claimed |
| EP-1178808-A1 | PHARMACEUTICAL COMPOSITION | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2002-02-13 | — | — | EP | claimed |
| US-20020012680-A1 | Compositions and methods for improved delivery of lipid regulating agents | LIPOCINE INC. | 2002-01-31 | — | — | US | claimed |
| WO-2000072827-A9 | POROUS DRUG MATRICES AND METHODS OF MANUFACTURE THEREOF | ACUSPHERE INC (US) | 2002-01-31 | — | — | WO | claimed |
| EP-1158959-A1 | COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF HYDROPHOBIC THERAPEUTIC AGENTS | Lipocine, Inc. (US) | 2001-12-05 | — | — | EP | claimed |
| US-6294192-B1 | PHARMACEUTICAL COMPOSITIONS CAPABLE OF SOLUBILIZING THERAPEUTICALLY EFFECTIVE AMOUNTS OF HYDROPHOBIC THERAPEUTIC AGENTS. CARRIER INCLUDES A HYDROPHILIC SURFACTANT AND A HYDROPHOBIC SURFACTANT, AQUEOUS DISPERSION | LIPOCINE, INC. | 2001-09-25 | — | — | US | claimed |
| WO-2001037808-A1 | SOLID CARRIERS FOR IMPROVED DELIVERY OF ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS | LIPOCINE, INC. (US) | 2001-05-31 | — | — | WO | claimed |
| WO-2001028555-A1 | EMULSION COMPOSITIONS FOR POLYFUNCTIONAL ACTIVE INGREDIENTS | LIPOCINE, INC. (US) | 2001-04-26 | — | — | WO | claimed |
| WO-2000072827-A2 | POROUS DRUG MATRICES AND METHODS OF MANUFACTURE THEREOF | ACUSPHERE, INC. (US) | 2000-12-07 | — | — | WO | claimed |
| WO-2000064450-A1 | PHARMACEUTICAL COMPOSITION | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 2000-11-02 | — | — | WO | claimed |
| WO-2000050007-A1 | COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF HYDROPHOBIC THERAPEUTIC AGENTS | LIPOCINE, INC. (US) | 2000-08-31 | — | — | WO | claimed |