Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30661185 | 0.84 | MAOA (0.47) | MAOAKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL3164530 | 0.84 | MAOA (0.47) | MAOAKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL18381826 | 0.83 | ALOX5 (0.42) | MAOAKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL23221668 | 0.81 | ALOX5 (0.41) | MAOAKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL19094401 | 0.80 | MAOA (0.50) | MAOAKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL16632966 | 0.79 | ALOX5 (0.46) | MAOAKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL8686 | 0.79 | ALOX5 (0.46) | MAOAKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL30392062 | 0.79 | ALOX5 (0.46) | MAOAKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL15112991 | 0.76 | ALOX5 (0.44) | MAOAKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL10759660 | 0.75 | MAOA (0.54) | MAOAKDM4ENPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225205-A1 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.p.A. (IT) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009077068-A9 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMA SPA (IT) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009077068-A1 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-06-25 | — | — | WO | disclosed |