Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023795 | 0.89 | ALDH1A1 (0.59) | ALDH1A1DRD2DRD3CHRNA7SLC6A2 | |
| SCHEMBL10795916 | 0.80 | CHRNA7 (0.59) | ALDH1A1KDM1ACHRNA7SLC6A2ADRA1A | |
| SCHEMBL5830164 | 0.80 | ALDH1A1 (0.51) | ALDH1A1KDM1ACHRNA7SLC6A2ADRA1A | |
| SCHEMBL27726403 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KDM1ACHRNA7SLC6A2ADRA1A | |
| SCHEMBL27517210 | 0.80 | ALDH1A1 (0.51) | ALDH1A1CHRNA7SLC6A2ADRA1AHTR2B | |
| SCHEMBL2257666 | 0.79 | SLC6A2 (0.58) | ALDH1A1CHRNA7SLC6A2ADRA1AHTR2B | |
| SCHEMBL460150 | 0.79 | SLC6A2 (0.58) | ALDH1A1CHRNA7SLC6A2ADRA1AHTR2B | |
| SCHEMBL8117490 | 0.76 | ALDH1A1 (0.47) | ALDH1A1DRD2DRD3CHRNA7SLC6A2 | |
| SCHEMBL28132486 | 0.76 | ALDH1A1 (0.51) | ALDH1A1KDM1ACHRNA7SLC6A2ADRA1A | |
| SCHEMBL11641230 | 0.76 | ALDH1A1 (0.51) | ALDH1A1CHRNA7SLC6A2ADRA1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101910155-A | Be used for the treatment of biphenyl derivatives with histamine-obstacle that the H3 receptor modulators is relevant as histamine-H3 receptor modulators | ARENA PHARM INC | 2010-12-08 | — | — | CN | disclosed |
| EP-2217592-A1 | BIPHENYL DERIVATIVES AS MODULATORS OF THE HISTAMINE-H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009058300-A1 | BIPHENYL DERIVATIVES AS MODULATORS OF THE HISTAMINE-H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2009-05-07 | — | — | WO | disclosed |