Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 4/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3013972 | 0.95 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1L3MBTL1HSD11B1MAPT | |
| SCHEMBL3002305 | 0.93 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1L3MBTL1HSD11B1MAPT | |
| SCHEMBL3651758 | 0.92 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1L3MBTL1MAPTUSP2 | |
| SCHEMBL3008545 | 0.91 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1L3MBTL1HSD11B1MAPT | |
| SCHEMBL3009001 | 0.90 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1L3MBTL1HSD11B1MAPT | |
| SCHEMBL3009990 | 0.90 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1L3MBTL1HSD11B1MAPT | |
| SCHEMBL3017633 | 0.90 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1L3MBTL1HSD11B1MAPT | |
| SCHEMBL3652321 | 0.90 | PKM (0.46) | SMN1; SMN2ALDH1A1L3MBTL1HSD11B1MAPT | |
| SCHEMBL3006932 | 0.89 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1L3MBTL1HSD11B1MAPT | |
| SCHEMBL3008158 | 0.89 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1L3MBTL1HSD11B1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |