Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.35 |
| ▸ | MUSK | O15146 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FER | P16591 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.35 |
| ▸ | MAP3K3 | Q99759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655264 | 1.00 | JAK2 (0.42) | JAK2PIK3CAPIK3CGKDRFLT1 | |
| SCHEMBL3651526 | 0.90 | SRC (0.37) | JAK2PIK3CAPIK3CGKDRFLT1 | |
| SCHEMBL3651523 | 0.90 | SRC (0.37) | JAK2PIK3CAPIK3CGKDRFLT1 | |
| SCHEMBL3030096 | 0.87 | JAK2 (0.42) | JAK2PIK3CAPIK3CGKDRFLT1 | |
| SCHEMBL3030101 | 0.87 | JAK2 (0.42) | JAK2PIK3CAPIK3CGKDRFLT1 | |
| Hydrochloric Acid SCHEMBL3025959 | 0.86 | JAK2 (0.41) | JAK2PIK3CAPIK3CGKDRFLT1 | |
| SCHEMBL3656602 | 0.81 | JAK2 (0.39) | JAK2PDGFRACDK4CDK2GSK3B | |
| SCHEMBL3658064 | 0.78 | HDAC3 (0.42) | JAK2KDRSYKZAP70PSEN1 | |
| SCHEMBL3026142 | 0.76 | LMNA (0.35) | JAK2SRC | |
| SCHEMBL3026134 | 0.76 | LMNA (0.35) | JAK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212309-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | Janssen Pharmaceutica N.V. (BE) | 2010-08-04 | — | — | EP | claimed |
| WO-2009050186-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-23 | — | — | WO | claimed |