Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.44 |
| ▸ | JAK3 | P52333 | 9/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3303680 | 0.84 | JAK2 (0.49) | JAK2JAK3PTK2PDE4BJAK1 | |
| SCHEMBL3262347 | 0.80 | JAK2 (0.61) | JAK2JAK3PTK2JAK1THRB | |
| SCHEMBL3263724 | 0.79 | JAK2 (0.45) | JAK2JAK3PTK2JAK1KDM4E | |
| SCHEMBL3261713 | 0.79 | JAK1 (0.64) | JAK2JAK3PTK2JAK1FLT3 | |
| SCHEMBL3266110 | 0.78 | JAK2 (0.55) | JAK2JAK3PTK2JAK1KDM4E | |
| SCHEMBL3262435 | 0.77 | JAK2 (0.55) | JAK2JAK3PTK2JAK1KDM4E | |
| SCHEMBL2144680 | 0.77 | JAK2 (0.51) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL7964132 | 0.76 | JAK2 (0.49) | JAK2JAK3PTK2JAK1NEK2 | |
| SCHEMBL7974556 | 0.76 | MEN1 (0.55) | JAK2JAK1KDM4ETHRBNPSR1 | |
| SCHEMBL3261150 | 0.74 | PLK1 (0.47) | JAK2JAK3PTK2JAK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |