Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.53 |
| ▸ | IKBKB | O14920 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655731 | 0.86 | BTK (0.54) | BTKIKBKBBRD4 | |
| SCHEMBL12602977 | 0.81 | BTK (0.53) | BTKBRD4 | |
| SCHEMBL4080600 | 0.78 | BTK (0.42) | BTKIKBKBKDM4E | |
| SCHEMBL4185338 | 0.78 | BTK (0.46) | BTK | |
| SCHEMBL3751476 | 0.77 | BTK (0.41) | BTK | |
| SCHEMBL103964 | 0.77 | BTK (0.81) | BTK | |
| SCHEMBL104029 | 0.77 | BTK (0.51) | BTK | |
| SCHEMBL106046 | 0.76 | BTK (0.64) | BTK | |
| SCHEMBL105185 | 0.76 | BTK (0.71) | BTK | |
| SCHEMBL3754627 | 0.74 | BTK (0.42) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205564-A1 | NOVEL KINASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |