Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 13/20 | 0.54 |
| ▸ | BRD4 | O60885 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655728 | 0.86 | BTK (0.53) | BTKBRD4IKBKB | |
| SCHEMBL12602977 | 0.83 | BTK (0.53) | BTKBRD4 | |
| SCHEMBL103964 | 0.78 | BTK (0.81) | BTK | |
| SCHEMBL104029 | 0.78 | BTK (0.51) | BTKSMN1; SMN2 | |
| SCHEMBL105185 | 0.78 | BTK (0.71) | BTK | |
| SCHEMBL106046 | 0.78 | BTK (0.64) | BTK | |
| SCHEMBL4080605 | 0.77 | BTK (0.43) | BTKALDH1A1RECQLSMN1; SMN2 | |
| SCHEMBL12650117 | 0.75 | BTK (0.58) | BTK | |
| SCHEMBL105874 | 0.75 | BTK (0.54) | BTKALDH1A1 | |
| SCHEMBL108970 | 0.75 | BTK (0.59) | BTKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205564-A1 | NOVEL KINASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |