Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1785668 | 0.92 | MAPT (0.54) | MAPTLMNAHTTMEN1KMT2A | |
| SCHEMBL4351617 | 0.79 | PRKDC (0.59) | MAPTHTTMEN1KMT2AJAK2 | |
| SCHEMBL1785344 | 0.79 | MAPT (0.58) | MAPTLMNAHTTMEN1KMT2A | |
| SCHEMBL1785686 | 0.78 | ALDH1A1 (0.50) | MAPTLMNAHTTKMT2AALDH1A1 | |
| SCHEMBL28190265 | 0.78 | PRKDC (0.55) | MAPTJAK2MAPK9MAPK10AKR1C3 | |
| SCHEMBL144733 | 0.76 | LGMN (0.59) | MAPTJAK2PRKDCJAK1TYK2 | |
| SCHEMBL552259 | 0.76 | PRKDC (0.60) | MAPTJAK2MAPK9MAPK10PRKDC | |
| SCHEMBL29039888 | 0.76 | MAPT (0.51) | MAPTLMNAHTTMEN1KMT2A | |
| SCHEMBL1786156 | 0.75 | MAPT (0.54) | MAPTLMNAHTTJAK2ALDH1A1 | |
| SCHEMBL3228970 | 0.75 | MAPT (0.56) | MAPTHTTMEN1KMT2AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205576-A1 | BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009047558-A1 | BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | WO | disclosed |